Formulation of highly functionalizable DNA nanoparticles based on 1,2-dithiolane derivatives.
Chembiochem
; 16(5): 792-804, 2015 Mar 23.
Article
em En
| MEDLINE
| ID: mdl-25689838
ABSTRACT
We describe the formulation of synthetic virus models based on ionic compounds bearing the polymerizable 1,2-dithiolane moiety. First, cationic amphiphiles containing the polymeric inducer were prepared and used to efficiently condense a DNA plasmid (pDNA) into a highly monodisperse population of small polymeric cationic DNA nanoparticles (NPs; Dh â¼100 nm). These nonspecific cationic particles were then functionalized with anionic PEGylated conjugates, also based on the 1,2-dithiolane motifs, in order to produce stable and fully dispersible stealth DNA nanoparticles. Our results show that both ionic interactions and polymerization based on the 1,2-dithiolane pattern occur and that they produce highly functionalizable nonviral DNA NPs.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
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Ácido Tióctico
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Nanopartículas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article