Integrative analysis of haplotype-resolved epigenomes across human tissues.
Nature
; 518(7539): 350-354, 2015 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-25693566
ABSTRACT
Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully explored. Here we delineate allelic chromatin modifications and transcriptomes among a broad set of human tissues, enabled by a chromosome-spanning haplotype reconstruction strategy. The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state and transcription, which show considerable variation across tissues and between individuals, and allow us to investigate cis-regulatory relationships between genes and their control sequences. Analyses of histone modification maps also uncover intriguing characteristics of cis-regulatory elements and tissue-restricted activities of repetitive elements. The rich data sets described here will enhance our understanding of the mechanisms by which cis-regulatory elements control gene expression programs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Haplótipos
/
Epigênese Genética
/
Alelos
/
Epigenômica
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article