[Impact of eradication of Pseudomonas aeruginosa on survival in Mexican patients with cystic fibrosis]. / Impacto de la erradicación de Pseudomonas aeruginosa sobre la sobrevida en pacientes con fibrosis quística del noreste de México.
Rev Invest Clin
; 66(4): 307-13, 2014.
Article
em Es
| MEDLINE
| ID: mdl-25695295
ABSTRACT
INTRODUCTION:
Patients with cystic fibrosis (CF) present lower airway infection with Pseudomonas aeruginosa. Treatment of initial infection is fundamental to reduce subsequent damage. MATERIAL ANDMETHODS:
We evaluated the efficacy of eradication treatment of P. aeruginosa in patients with CF from northeast Mexico using two protocols inhaled colistin/oral ciprofloxacin and nebulized tobramycin 300 mg/oral ciprofloxacin. The intervention group included 17 patients with CF and recent infection with P. aeruginosa. The control group consisted of 23 chronically colonized patients of comparable age.RESULTS:
Patients received 27 courses of eradication treatment. P. aeruginosa was eradicated in 21/27 (77.77%). The infection free period was 16.9, 11.7 months (colistin) and 17 ± 9.7 months (tobramycin) with no statistically significant difference (P = 0.97).CONCLUSIONS:
Treated patients maintained normal lung function, better nutritional status, and a better chest X-ray score. In the control group 17/23 (73.9%) patients died with no deaths in the study group.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
/
Infecções por Pseudomonas
/
Fibrose Cística
/
Antibacterianos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Mexico
Idioma:
Es
Ano de publicação:
2014
Tipo de documento:
Article