Dynamic combinatorial enrichment of polyconformational D-/L-peptide dimers.
Chemistry
; 21(15): 5898-908, 2015 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-25711604
ABSTRACT
D-/L-peptides such as gramicidinâ
A (gA) adopt unique dimeric ß-helical structures of different topologies. To overcome their conformational promiscuity and enrich individual components, a dynamic combinatorial approach assisted by thiol tags was developed. This method led to identification of the preferential formation of antiparallel dimers under a broad range of conditions, which was independent of peptide side-chain polarity. Exclusive formation of an antiparallel cyclic dimer was achieved in the presence of cesium ions.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Compostos de Sulfidrila
/
Gramicidina
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article