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Eculizumab in pregnancy-associated atypical hemolytic uremic syndrome: insights for optimizing management.
De Sousa Amorim, Erika; Blasco, Miquel; Quintana, Luis; Sole, Manel; de Cordoba, Santiago Rodríguez; Campistol, Josep Maria.
Afiliação
  • De Sousa Amorim E; Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain. desousa@clinic.ub.es.
  • Blasco M; Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain.
  • Quintana L; Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain.
  • Sole M; Histopathology Department, Hospital Clinic, Barcelona, Spain.
  • de Cordoba SR; Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040, Madrid, Spain.
  • Campistol JM; Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain.
J Nephrol ; 28(5): 641-5, 2015 Oct.
Article em En | MEDLINE | ID: mdl-25712233
Pregnancy-associated atypical hemolytic uremic syndrome is a systemic disease associated with high morbidity and mortality rates, caused by dysregulation of the alternative complement pathway, leading to uncontrolled complement activation resulting in thrombotic microangiopathy. This condition can be effectively treated by anti-C5 therapy, which controls complement activation. Treatment can be safely discontinued after complete remission and resolution of the precipitating cause, especially in patients with a low-risk genetic profile.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Gerenciamento Clínico / Anticorpos Monoclonais Humanizados / Síndrome Hemolítico-Urêmica Atípica Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Gerenciamento Clínico / Anticorpos Monoclonais Humanizados / Síndrome Hemolítico-Urêmica Atípica Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2015 Tipo de documento: Article