Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway.

Shang, Guoguo; Tang, Xinjun; Gao, Pan; Guo, Fanli; Liu, Hongpeng; Zhao, Zhonghua; Chen, Qi; Jiang, Tao; Zhang, Nong; Li, Hui

Shang, Guoguo; Tang, Xinjun; Gao, Pan; Guo, Fanli; Liu, Hongpeng; Zhao, Zhonghua; Chen, Qi; Jiang, Tao; Zhang, Nong; Li, Hui.

Afiliação

Shang G; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Tang X; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Gao P; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Guo F; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Liu H; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Zhao Z; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Chen Q; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Jiang T; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Zhang N; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
Li H; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China. Electronic address: huili78@fudan.edu.cn.

J Nutr Biochem ; 26(6): 596-606, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25724107

Assuntos

Diabetes Mellitus Experimental/prevenção & controle; Nefropatias Diabéticas/prevenção & controle; Quinase 3 da Glicogênio Sintase/metabolismo; Isotiocianatos/farmacologia; Fator 2 Relacionado a NF-E2/metabolismo; Proteínas Proto-Oncogênicas c-fyn/metabolismo; Transdução de Sinais; 8-Hidroxi-2'-Desoxiguanosina; Animais; Antioxidantes/farmacologia; Células Cultivadas; Colágeno Tipo IV/genética; Colágeno Tipo IV/metabolismo; Dano ao DNA; Desoxiguanosina/análogos & derivados; Desoxiguanosina/metabolismo; Diabetes Mellitus Experimental/metabolismo; Nefropatias Diabéticas/metabolismo; Fibronectinas/genética; Fibronectinas/metabolismo; Quinase 3 da Glicogênio Sintase/genética; Glicogênio Sintase Quinase 3 beta; Masculino; Células Mesangiais/efeitos dos fármacos; Fator 2 Relacionado a NF-E2/genética; Estresse Oxidativo; Fosforilação; Proteínas Proto-Oncogênicas c-fyn/genética; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Ratos; Ratos Sprague-Dawley; Sulfóxidos; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

Diabetic nephropathy; Fyn; Glycogen synthase kinase 3 beta; Mesangial cells; Nrf2; Sulforaphane

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Isotiocianatos / Quinase 3 da Glicogênio Sintase / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Proteínas Proto-Oncogênicas c-fyn / Fator 2 Relacionado a NF-E2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google