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Poor thiamin and riboflavin status is common among women of childbearing age in rural and urban Cambodia.
Whitfield, Kyly C; Karakochuk, Crystal D; Liu, Yazheng; McCann, Adrian; Talukder, Aminuzzaman; Kroeun, Hou; Ward, Mary; McNulty, Helene; Lynd, Larry D; Kitts, David D; Li-Chan, Eunice C Y; McLean, Judy; Green, Timothy J.
Afiliação
  • Whitfield KC; Food, Nutrition, and Health and.
  • Karakochuk CD; Food, Nutrition, and Health and.
  • Liu Y; Food, Nutrition, and Health and.
  • McCann A; Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland; and.
  • Talukder A; Helen Keller International, Phnom Penh, Cambodia.
  • Kroeun H; Helen Keller International, Phnom Penh, Cambodia.
  • Ward M; Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland; and.
  • McNulty H; Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland; and.
  • Lynd LD; Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada;
  • Kitts DD; Food, Nutrition, and Health and.
  • Li-Chan EC; Food, Nutrition, and Health and.
  • McLean J; Food, Nutrition, and Health and.
  • Green TJ; Food, Nutrition, and Health and tim.green@ubc.ca.
J Nutr ; 145(3): 628-33, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25733481
ABSTRACT

BACKGROUND:

Thiamin deficiency in infancy is the underlying cause of beriberi, which can be fatal without rapid treatment. Reports of thiamin deficiency are common in Cambodia; however, population representative data are unavailable. Because B-complex vitamin deficiencies commonly occur in combination, riboflavin was also investigated.

OBJECTIVE:

We determined the biomarker status of thiamin and riboflavin in women of childbearing age in rural and urban Cambodia.

METHODS:

We measured thiamin (erythrocyte thiamin diphosphate; TDP) and riboflavin (erythrocyte glutathione reductase activity coefficient; EGRac) status in a representative sample of Cambodian women (aged 20-45 y) in urban Phnom Penh (n = 146) and rural Prey Veng (n = 156), Cambodia, and, for comparison purposes, in a convenience sample of women in urban Vancouver, British Columbia, Canada (n = 49).

RESULTS:

Thiamin insufficiency (TDP ≤ 90 nmol/L) was common among both urban (39%) and rural (59%) Cambodian women (P < 0.001), whereas <20% of Vancouver women were thiamin insufficient (P < 0.001). The prevalence of suboptimal and deficient riboflavin status (EGRac ≥ 1.3) was 89%, 92%, and 70% among women in Phnom Penh, Prey Veng, and Vancouver, respectively (P < 0.001).

CONCLUSIONS:

Suboptimal status of both thiamin and riboflavin were common in Cambodian women, with substantially higher rates among women living in rural Prey Veng than in urban Phnom Penh. Strategies may be needed to improve the thiamin and riboflavin status of women in Cambodia. The unexpected finding of high riboflavin inadequacy status in Vancouver women warrants further investigation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Riboflavina / População Rural / Deficiência de Tiamina / População Urbana / Estado Nutricional Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do norte / Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Riboflavina / População Rural / Deficiência de Tiamina / População Urbana / Estado Nutricional Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do norte / Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article