Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice.

Bostick, Brian; Habibi, Javad; DeMarco, Vincent G; Jia, Guanghong; Domeier, Timothy L; Lambert, Michelle D; Aroor, Annayya R; Nistala, Ravi; Bender, Shawn B; Garro, Mona; Hayden, Melvin R; Ma, Lixin; Manrique, Camila; Sowers, James R

Bostick, Brian; Habibi, Javad; DeMarco, Vincent G; Jia, Guanghong; Domeier, Timothy L; Lambert, Michelle D; Aroor, Annayya R; Nistala, Ravi; Bender, Shawn B; Garro, Mona; Hayden, Melvin R; Ma, Lixin; Manrique, Camila; Sowers, James R.

Afiliação

Bostick B; Division of Cardiovascular Medicine, Department of Medicine, University of Missouri, Columbia, Missouri;
Habibi J; Division of Endocrinology, Diabetes and Metabolism, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
DeMarco VG; Division of Endocrinology, Diabetes and Metabolism, University of Missouri, Columbia, Missouri; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
Jia G; Division of Endocrinology, Diabetes and Metabolism, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
Domeier TL; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri;
Lambert MD; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri;
Aroor AR; Division of Endocrinology, Diabetes and Metabolism, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
Nistala R; Division of Nephrology, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
Bender SB; Department of Biomedical Sciences, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and Dalton Cardiovascular Research Center, Columbia, Missouri.
Garro M; Division of Endocrinology, Diabetes and Metabolism, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
Hayden MR; Division of Endocrinology, Diabetes and Metabolism, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
Ma L; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
Manrique C; Division of Endocrinology, Diabetes and Metabolism, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and.
Sowers JR; Division of Endocrinology, Diabetes and Metabolism, University of Missouri, Columbia, Missouri; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; and Dalton Cardiovascular R

Am J Physiol Heart Circ Physiol ; 308(9): H1126-35, 2015 May 01.

Article em En | MEDLINE | ID: mdl-25747754

Assuntos

Diástole/efeitos dos fármacos; Dieta Ocidental; Ventrículos do Coração/efeitos dos fármacos; Antagonistas de Receptores de Mineralocorticoides/administração & dosagem; Receptores de Mineralocorticoides/efeitos dos fármacos; Espironolactona/administração & dosagem; Disfunção Ventricular Esquerda/prevenção & controle; Função Ventricular Esquerda/efeitos dos fármacos; Animais; Cardiomegalia/patologia; Cardiomegalia/fisiopatologia; Cardiomegalia/prevenção & controle; Dieta Hiperlipídica; Sacarose Alimentar; Modelos Animais de Doenças; Feminino; Fibrose; Frutose; Ventrículos do Coração/imunologia; Ventrículos do Coração/metabolismo; Ventrículos do Coração/patologia; Ventrículos do Coração/fisiopatologia; Mediadores da Inflamação/metabolismo; Camundongos Endogâmicos C57BL; Miócitos Cardíacos/efeitos dos fármacos; Miócitos Cardíacos/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Receptores de Mineralocorticoides/metabolismo; Proteínas Quinases S6 Ribossômicas 90-kDa/metabolismo; Sarcômeros/efeitos dos fármacos; Sarcômeros/metabolismo; Fatores Sexuais; Fatores de Tempo; Disfunção Ventricular Esquerda/etiologia; Disfunção Ventricular Esquerda/imunologia; Disfunção Ventricular Esquerda/metabolismo; Disfunção Ventricular Esquerda/patologia; Disfunção Ventricular Esquerda/fisiopatologia; Pressão Ventricular/efeitos dos fármacos; Remodelação Ventricular/efeitos dos fármacos

Palavras-chave

aldosterone; cardiac hypertrophy; high-fat diet; high-fructose diet; inflammation; low-dose spironolactone; mineralocorticoid antagonism; myocardial compliance; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espironolactona / Função Ventricular Esquerda / Receptores de Mineralocorticoides / Disfunção Ventricular Esquerda / Diástole / Antagonistas de Receptores de Mineralocorticoides / Dieta Ocidental / Ventrículos do Coração Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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