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Integrin ß1 controls VE-cadherin localization and blood vessel stability.
Yamamoto, Hiroyuki; Ehling, Manuel; Kato, Katsuhiro; Kanai, Kenichi; van Lessen, Max; Frye, Maike; Zeuschner, Dagmar; Nakayama, Masanori; Vestweber, Dietmar; Adams, Ralf H.
Afiliação
  • Yamamoto H; 1] Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany [2] Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany.
  • Ehling M; 1] Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany [2] Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany.
  • Kato K; 1] Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany [2] Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany.
  • Kanai K; 1] Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany [2] Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany.
  • van Lessen M; 1] Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany [2] Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany.
  • Frye M; Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany.
  • Zeuschner D; Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany.
  • Nakayama M; 1] Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany [2] Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany.
  • Vestweber D; Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany.
  • Adams RH; 1] Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany [2] Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany.
Nat Commun ; 6: 6429, 2015 Mar 10.
Article em En | MEDLINE | ID: mdl-25752958
Angiogenic blood vessel growth requires several distinct but integrated cellular activities. Endothelial cell sprouting and proliferation lead to the expansion of the vasculature and give rise to a highly branched, immature plexus, which is subsequently reorganized into a mature and stable network. Although it is known that integrin-mediated cell-matrix interactions are indispensable for embryonic angiogenesis, little is known about the function of integrins in different steps of vascular morphogenesis. Here, by investigating the integrin ß1-subunit with inducible and endothelial-specific gene targeting in the postnatal mouse retina, we show that ß1 integrin promotes endothelial sprouting but is a negative regulator of proliferation. In maturing vessels, integrin ß1 is indispensable for proper localization of VE-cadherin and thereby cell-cell junction integrity. The sum of our findings establishes that integrin ß1 has critical functions in the growing and maturing vasculature, and is required for the formation of stable, non-leaky blood vessels.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasos Retinianos / Antígenos CD / Caderinas / Neovascularização Fisiológica / Integrina beta1 / Endotélio / Junções Intercelulares / Morfogênese Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasos Retinianos / Antígenos CD / Caderinas / Neovascularização Fisiológica / Integrina beta1 / Endotélio / Junções Intercelulares / Morfogênese Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article