Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44(+)/CD24(-/low)): an in vitro study.

Ahmadipour, Fatemeh; Noordin, Mohamed Ibrahim; Mohan, Syam; Arya, Aditya; Paydar, Mohammadjavad; Looi, Chung Yeng; Keong, Yeap Swee; Siyamak, Ebrahimi Nigjeh; Fani, Somayeh; Firoozi, Maryam; Yong, Chung Lip; Sukari, Mohamed Aspollah; Kamalidehghan, Behnam

Ahmadipour, Fatemeh; Noordin, Mohamed Ibrahim; Mohan, Syam; Arya, Aditya; Paydar, Mohammadjavad; Looi, Chung Yeng; Keong, Yeap Swee; Siyamak, Ebrahimi Nigjeh; Fani, Somayeh; Firoozi, Maryam; Yong, Chung Lip; Sukari, Mohamed Aspollah; Kamalidehghan, Behnam.

Afiliação

Ahmadipour F; Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Noordin MI; Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Mohan S; Medical Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia.
Arya A; Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Paydar M; Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Looi CY; Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Keong YS; UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.
Siyamak EN; UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.
Fani S; Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Firoozi M; Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
Yong CL; Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Sukari MA; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Malaysia.
Kamalidehghan B; Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Drug Des Devel Ther ; 9: 1193-208, 2015.

Article em En | MEDLINE | ID: mdl-25759564

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Produtos Biológicos/farmacologia; Neoplasias da Mama/patologia; Antígeno CD24/metabolismo; Carbazóis/farmacologia; Receptores de Hialuronatos/metabolismo; Murraya/química; Células-Tronco Neoplásicas/patologia; Antineoplásicos Fitogênicos/química; Antineoplásicos Fitogênicos/isolamento & purificação; Apoptose/efeitos dos fármacos; Produtos Biológicos/química; Produtos Biológicos/isolamento & purificação; Biomarcadores Tumorais/análise; Biomarcadores Tumorais/metabolismo; Neoplasias da Mama/metabolismo; Antígeno CD24/análise; Carbazóis/química; Carbazóis/isolamento & purificação; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Receptores de Hialuronatos/análise; Células MCF-7; Células-Tronco Neoplásicas/metabolismo; Relação Estrutura-Atividade; Células Tumorais Cultivadas

Palavras-chave

MCF7 breast cancer stem cells; Murraya koenigii (L) Spreng; Wnt/ß-catenin; glycogen synthase kinase 3ß; koenimbin; nuclear factor kappa B

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Produtos Biológicos / Neoplasias da Mama / Carbazóis / Receptores de Hialuronatos / Murraya / Antígeno CD24 / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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