The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.

Ren, Yaguang; Chen, Sixi; Ma, Mengmeng; Yao, Xiuping; Sun, Dayan; Li, Bin; Lu, Jianxin

Ren, Yaguang; Chen, Sixi; Ma, Mengmeng; Yao, Xiuping; Sun, Dayan; Li, Bin; Lu, Jianxin.

Afiliação

Ren Y; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Chen S; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Ma M; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Yao X; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Sun D; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Li B; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Lu J; Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: jxlu313@163.com.

Exp Gerontol ; 65: 53-7, 2015 May.

Article em En | MEDLINE | ID: mdl-25769692

Assuntos

Envelhecimento/fisiologia; Proteínas de Caenorhabditis elegans/genética; Proteínas de Transporte de Cátions/genética; Transporte de Elétrons/genética; Longevidade/genética; Animais; Caenorhabditis elegans; Proteínas de Caenorhabditis elegans/metabolismo; Expectativa de Vida; Proteínas Mitocondriais/metabolismo; Proteínas Quinases/metabolismo; Resposta a Proteínas não Dobradas/fisiologia

Palavras-chave

C. elegans; GCN-2; Lifespan; Mitochondrial dysfunctions; Mitochondrial unfolded protein response; Protein homeostasis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Proteínas de Transporte de Cátions / Proteínas de Caenorhabditis elegans / Transporte de Elétrons / Longevidade Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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