The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration.
Cancer Lett
; 361(2): 185-96, 2015 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-25796438
ABSTRACT
Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Proteínas Serina-Treonina Quinases
/
Quinases Associadas a rho
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Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article