Antimicrobial photodynamic activity of hypericin against methicillin-susceptible and resistant Staphylococcus aureus biofilms.
Future Microbiol
; 10(3): 347-56, 2015.
Article
em En
| MEDLINE
| ID: mdl-25812458
ABSTRACT
AIM:
To evaluate the effectiveness of the photodynamic therapy using hypericin (HYP) against both planktonic and biofilm-forming Staphylococcus aureus. MATERIALS &METHODS:
HYP photoactivity was evaluated against methicillin-susceptible and resistant S. aureus. Bacterial suspension or biofilm were preincubated with HYP and subjected to LED illumination. Viable bacteria were determined by colony counting.RESULTS:
Preincubation with HYP (5 min) plus light exposure (10 min) showed bactericidal effect against planktonic methicillin-susceptible S. aureus and methicillin-resistant S. aureus. Longer preincubation times (24 h) and time light exposure (30 min) were required to reach HYP-photoactivity against S. aureus biofilms. HYP-photoactivity was correlated to the biofilm production.CONCLUSION:
HYP could be a potential photosensitizer for the inactivation of staphylococcal biofilms forming on the surfaces accessible to visible light.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Perileno
/
Fotoquimioterapia
/
Staphylococcus aureus
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Fármacos Fotossensibilizantes
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Biofilmes
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Staphylococcus aureus Resistente à Meticilina
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article