Activity of clarithromycin or rifampin alone or in combination against experimental Rhodococcus equi infection in mice.
Antimicrob Agents Chemother
; 59(6): 3633-6, 2015.
Article
em En
| MEDLINE
| ID: mdl-25824218
ABSTRACT
Treatment of mice with the combination of clarithromycin with rifampin resulted in a significantly lower number of Rhodococcus equi CFU in the organs of mice than treatment with either drug alone or placebo. There was no significant difference in the number of R. equi CFU between mice treated with clarithromycin monotherapy, rifampin monotherapy, or placebo. The combination of clarithromycin with rifampin conferred a clear advantage over either drug as monotherapy in this model of chronic R. equi infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rifampina
/
Infecções por Actinomycetales
/
Rhodococcus equi
/
Claritromicina
/
Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article