Adverse Impact of Maternal Cigarette Smoking on Preterm Infants: A Population-Based Cohort Study.
Am J Perinatol
; 32(12): 1105-11, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-25825966
ABSTRACT
OBJECTIVE:
The aim of the study is to examine the impact of exposure to maternal cigarette smoking on neonatal outcomes of very preterm infants. STUDYDESIGN:
A retrospective cohort study examined preterm infants (<33 weeks gestational age) admitted to the Canadian Neonatal Network centers between 2003 and 2011. Mortality and major morbidities (bronchopulmonary dysplasia, severe intraventricular hemorrhage, necrotizing enterocolitis, and retinopathy) were compared between infants exposed and unexposed to maternal smoking during pregnancy after adjusting for confounders.RESULTS:
Among 29,051 study infants, 4,053 (14%) were exposed to maternal smoking during pregnancy. Multivariable analysis revealed higher odds of grade 3 or 4 intraventricular hemorrhage or periventricular leukomalacia (adjusted odds ratio [OR] 1.21, 95% confidence interval [CI] 1.04-1.41) and bronchopulmonary dysplasia (adjusted OR 1.16, 95% CI 1.02-1.33) in the smoking group, while mortality, severe retinopathy, and necrotizing enterocolitis were not significantly different.CONCLUSION:
Maternal smoking during pregnancy is associated with severe neurological injury and bronchopulmonary dysplasia in preterm infants.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucomalácia Periventricular
/
Displasia Broncopulmonar
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Fumar
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Hemorragia Cerebral
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Mortalidade Infantil
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Lactente Extremamente Prematuro
/
Comportamento Materno
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Infant
/
Male
/
Newborn
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article