A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: a Children's Oncology Group study.
Br J Haematol
; 170(1): 118-22, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25833390
ABSTRACT
A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (<30 years) treated with two to four cycles of IVB. The primary endpoint was anatomic complete response (CR) after two cycles. Secondary endpoints included overall response (OR CR + partial response) at study completion compared to historical controls [72%; 95% confidence interval (CI) 59-83%]. Although few patients achieved the primary objective, OR with IVB improved to 83% (95% CI 61-95%; p = 0.32). Although not statistically different, results suggest IVB may be a promising combination.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Hodgkin
/
Protocolos de Quimioterapia Combinada Antineoplásica
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Child
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Child, preschool
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article