Osteoporosis--a risk factor for cardiovascular diseases: a follow-up study.
Srp Arh Celok Lek
; 143(1-2): 28-34, 2015.
Article
em En
| MEDLINE
| ID: mdl-25845249
ABSTRACT
INTRODUCTION:
Cardiovascular (CV) diseases and bone fractures due to osteoporosis are the leading causes of death in the elderly.OBJECTIVE:
The aim of this study was to demonstrate a correlation between the overall risk for CV events, and low bone density in postmenopausal women, and its impact on the incidence of serious CV events.METHODS:
Our prospective study involved 300 postmenopausal women. All the examinees were divided into three groups based on their measured bone density Group I--84 examinees with osteoporosis; Group II--115 examinees with osteopenia; and Group III--101 examinees with normal bone density. In all examinees the overall ten-year risk for a fatal CV event was calculated using the SCORE system tables.RESULTS:
After a 36-month follow-up, CV events occurred in 19 (6.3%) examinees. Significant differences in the incidence of CV events were demonstrated between the patients with osteoporosis, osteopenia, and normal bone density (χ2 = 28.7; p < 0.001), as well as between those with a high and low CV risk (χ2 = 22.6; p < 0.001). Multivariate logistic regression analysis showed that smoking (OR 2.23; 95% CI 1.02 to 6.19; p = 0.035), and increase of overall CV score (OR 1.36; 95% CI 1.17 to 1.58; p < 0.001) are associated with increased CV event risk, while the increase of T score value is associated with decreased risk of CV event (OR 0.42; 95% CI 0.25 to 0.73; p = 0.002).CONCLUSION:
Measurement of bone density with a standard assessment of the total CV risk could be useful for selecting women who need intensive prevention and treatment of atherosclerosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Osteoporose Pós-Menopausa
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article