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Development of methyl isoxazoleazepines as inhibitors of BET.
Hewitt, Michael C; Leblanc, Yves; Gehling, Victor S; Vaswani, Rishi G; Côté, Alexandre; Nasveschuk, Christopher G; Taylor, Alexander M; Harmange, Jean-Christophe; Audia, James E; Pardo, Eneida; Cummings, Rich; Joshi, Shivangi; Sandy, Peter; Mertz, Jennifer A; Sims, Robert J; Bergeron, Louise; Bryant, Barbara M; Bellon, Steve; Poy, Florence; Jayaram, Hariharan; Jayaran, Hariharan; Tang, Yong; Albrecht, Brian K.
Afiliação
  • Hewitt MC; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA. Electronic address: mike.hewitt@constellationpharma.com.
  • Leblanc Y; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Gehling VS; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Vaswani RG; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Côté A; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Nasveschuk CG; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Taylor AM; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Harmange JC; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Audia JE; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Pardo E; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Cummings R; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Joshi S; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Sandy P; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Mertz JA; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Sims RJ; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Bergeron L; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Bryant BM; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Bellon S; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Poy F; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Jayaran H; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Tang Y; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
  • Albrecht BK; Constellation Pharmaceuticals, 215 First St., Suite 200, Cambridge, MA 02142, USA.
Bioorg Med Chem Lett ; 25(9): 1842-8, 2015 May 01.
Article em En | MEDLINE | ID: mdl-25851940
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxazóis / Azepinas / Fatores de Transcrição / Proteínas Nucleares / Desenho de Fármacos / Proteínas de Ligação a RNA / Proteínas Serina-Treonina Quinases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxazóis / Azepinas / Fatores de Transcrição / Proteínas Nucleares / Desenho de Fármacos / Proteínas de Ligação a RNA / Proteínas Serina-Treonina Quinases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article