RAS mutations vary between lesions in synchronous primary colorectal cancer: testing only one lesion is not sufficient to guide anti-EGFR treatment decisions.

de Macedo, Mariana Petaccia; de Melo, Fernanda Machado; Ribeiro, Júlia da Silva; de Mello, Celso Abdon Lopes; de Souza Begnami, Maria Dirlei Ferreira; Soares, Fernando Augusto; Carraro, Dirce Maria; da Cunha, Isabela Werneck

de Macedo, Mariana Petaccia; de Melo, Fernanda Machado; Ribeiro, Júlia da Silva; de Mello, Celso Abdon Lopes; de Souza Begnami, Maria Dirlei Ferreira; Soares, Fernando Augusto; Carraro, Dirce Maria; da Cunha, Isabela Werneck.

Afiliação

de Macedo MP; Department of Molecular Diagnosis, Anatomic Pathology Department, AC Camargo Cancer Center, São Paulo, Brazil ; Laboratory of Investigative Pathology, CIPE / AC Camargo Cancer Center, São Paulo, Brazil.
de Melo FM; Department of Molecular Diagnosis, Anatomic Pathology Department, AC Camargo Cancer Center, São Paulo, Brazil.
Ribeiro Jda S; Department of Molecular Diagnosis, Anatomic Pathology Department, AC Camargo Cancer Center, São Paulo, Brazil.
de Mello CA; Department of Clinical Oncology, AC Camargo Cancer Center, São Paulo, Brazil.
de Souza Begnami MD; Department of Molecular Diagnosis, Anatomic Pathology Department, AC Camargo Cancer Center, São Paulo, Brazil ; Laboratory of Investigative Pathology, CIPE / AC Camargo Cancer Center, São Paulo, Brazil.
Soares FA; Department of Molecular Diagnosis, Anatomic Pathology Department, AC Camargo Cancer Center, São Paulo, Brazil ; Laboratory of Investigative Pathology, CIPE / AC Camargo Cancer Center, São Paulo, Brazil.
Carraro DM; Department of Molecular Diagnosis, Anatomic Pathology Department, AC Camargo Cancer Center, São Paulo, Brazil ; Laboratory of Genomics and Molecular Biology, CIPE / AC Camargo Cancer Center, São Paulo, Brazil.
da Cunha IW; Department of Molecular Diagnosis, Anatomic Pathology Department, AC Camargo Cancer Center, São Paulo, Brazil ; Laboratory of Investigative Pathology, CIPE / AC Camargo Cancer Center, São Paulo, Brazil.

Oncoscience ; 2(2): 125-30, 2015.

Article em En | MEDLINE | ID: mdl-25859555

Palavras-chave

KRAS; NRAS; anti-EGFR treatment; colorectal cancer; synchronic primary colorectal cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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