PIGS: improved estimates of identity-by-descent probabilities by probabilistic IBD graph sampling.
BMC Bioinformatics
; 16 Suppl 5: S9, 2015.
Article
em En
| MEDLINE
| ID: mdl-25860540
ABSTRACT
Identifying segments in the genome of different individuals that are identical-by-descent (IBD) is a fundamental element of genetics. IBD data is used for numerous applications including demographic inference, heritability estimation, and mapping disease loci. Simultaneous detection of IBD over multiple haplotypes has proven to be computationally difficult. To overcome this, many state of the art methods estimate the probability of IBD between each pair of haplotypes separately. While computationally efficient, these methods fail to leverage the clique structure of IBD resulting in less powerful IBD identification, especially for small IBD segments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Haplótipos
/
Genoma Humano
/
Biologia Computacional
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Polimorfismo de Nucleotídeo Único
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Genética Populacional
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article