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Cytotoxic prenylated flavonoids from Macaranga indica.
Yang, Da-Song; Peng, Wei-Bing; Yang, Yong-Ping; Liu, Ke-Chun; Li, Xiao-Li; Xiao, Wei-Lie.
Afiliação
  • Yang DS; Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
  • Peng WB; Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
  • Yang YP; Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
  • Liu KC; Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
  • Li XL; Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: li_xiaoli11@mail.kib.ac.cn.
  • Xiao WL; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: xwl@mail.kib.ac.cn.
Fitoterapia ; 103: 187-91, 2015 Jun.
Article em En | MEDLINE | ID: mdl-25861749
ABSTRACT
Three new prenylated flavonoids, macarindicins A-C (1-3), as well as seven known compounds (4-10) were isolated from the twigs of Macaranga indica. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 2 and 3 enriched the diversity of prenyl moiety in genus Macaranga especially in the aspect of various lengths of prenyl chain. All the known compounds were isolated from M. indica for the first time and this plant was found to contain large number of ellagic acid. Compounds 1-10 were tested for their cytotoxicity against four cancer cell lines (MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range of 2.61-20.35 µg/mL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Extratos Vegetais / Euphorbiaceae / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Extratos Vegetais / Euphorbiaceae / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article