A micelle-like structure of poloxamer-methotrexate conjugates as nanocarrier for methotrexate delivery.

Ren, Jin; Fang, Zhengjie; Yao, Li; Dahmani, Fatima Zohra; Yin, Lifang; Zhou, Jianping; Yao, Jing

Ren, Jin; Fang, Zhengjie; Yao, Li; Dahmani, Fatima Zohra; Yin, Lifang; Zhou, Jianping; Yao, Jing.

Afiliação

Ren J; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China; Jiangsu Key Laboratory of Target Drug and Clinial Application, School of Pharmacy, Xuzhou Medical College, 209 Tongshanlu, Xuzhou 221004, China.
Fang Z; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Yao L; Department of Pharmaceutics, Siping central People's Hospital, 89 Yingbinjie, Siping 136000, China.
Dahmani FZ; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Yin L; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Zhou J; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address: zhoujpcpu@163.com.
Yao J; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address: yaoj3@163.com.

Int J Pharm ; 487(1-2): 177-86, 2015 Jun 20.

Article em En | MEDLINE | ID: mdl-25865570

Assuntos

Antimetabólitos/administração & dosagem; Antimetabólitos/química; Metotrexato/administração & dosagem; Metotrexato/química; Nanopartículas; Animais; Antimetabólitos/farmacocinética; Preparações de Ação Retardada; Portadores de Fármacos; Composição de Medicamentos; Sistemas de Liberação de Medicamentos; Ésteres/química; Masculino; Metotrexato/farmacocinética; Micelas; Tamanho da Partícula; Poloxâmero; Ratos; Ratos Sprague-Dawley; Solubilidade

Palavras-chave

Bioavailability; Biphasic release; Dicyclohexylcarbodiimide (PubChem CID: 10868); Dicyclohexylurea (PubChem CID: 4277); Dimethylaminopyridine (PubChem CID: 14284); MTX; Methanol (PubChem CID: 887); Methotrexate (PubChem CID: 24897373); Micelles; N,N-dimethylformamide (PubChem CID: 6228); N-hydroxysuccinimide (PubChem CID: 80170); Poloxamer; Poloxamer (PubChem CID: 10129990); Pyrene (PubChem CID: 31423); Theophylline (PubChem CID: 2153)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metotrexato / Nanopartículas / Antimetabólitos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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