Your browser doesn't support javascript.
loading
A case of anti-N-methyl-d-aspartate receptor encephalitis with multiple sclerosis-like demyelinated lesions.
Takeda, Akitoshi; Shimada, Hiroyuki; Tamura, Akiko; Yasui, Masaaki; Yamamoto, Kei-Ichi; Itoh, Kazuhiro; Ataka, Suzuka; Tanaka, Sayaka; Ohsawa, Masahiko; Hatsuta, Hiroyuki; Hirano, Makito; Sakamoto, Hikaru; Ueno, Shuichi; Nakamura, Yusaku; Tsutada, Tsuyoshi; Miki, Takami.
Afiliação
  • Takeda A; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan. Electronic address: a-taked@med.osaka-cu.ac.jp.
  • Shimada H; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Tamura A; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Yasui M; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Yamamoto K; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Itoh K; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Ataka S; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Tanaka S; Department of Diagnostic Pathology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Ohsawa M; Department of Diagnostic Pathology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Hatsuta H; Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
  • Hirano M; Department of Neurology, Sakai Hospital, Kinki University Faculty of Medicine, Osaka, Japan.
  • Sakamoto H; Department of Neurology, Sakai Hospital, Kinki University Faculty of Medicine, Osaka, Japan.
  • Ueno S; Department of Neurology, Sakai Hospital, Kinki University Faculty of Medicine, Osaka, Japan.
  • Nakamura Y; Department of Neurology, Sakai Hospital, Kinki University Faculty of Medicine, Osaka, Japan.
  • Tsutada T; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Miki T; Department of Geriatric Medicine and Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
Mult Scler Relat Disord ; 3(3): 391-7, 2014 May.
Article em En | MEDLINE | ID: mdl-25876479
OBJECTIVE: To describe an unusual case of a male patient with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis who presented with multiple white matter lesions. Brain biopsy of the patient was performed, and follow-up evaluation of the cerebrospinal fluid (CSF) NMDAR antibody titer was implemented. DESIGN: Case report. SETTING: University hospital. PATIENT: A 35-year-old man with anti-NMDAR encephalitis initially presented with fever and psychiatric symptoms. After an initial attack of anti-NMDAR encephalitis, 2 atypical relapses occurred, which presented with myelitis and multifocal white matter lesions; the lesions were open-ring-shaped and partially enhanced. INTERVENTION: Analysis of the brain biopsy specimen revealed the presence of demyelinated lesions with discrete borders. Subsequent intravenous methylprednisolone therapy resulted in improvement in the brain lesions. Prednisolone and cyclophosphamide were orally administered thereafter. Clinical progression of the disease paralleled observed changes in the CSF NMDAR antibody titer. CONCLUSION: The demyelinated lesions observed in this case were similar to lesions found in multiple sclerosis. On the basis of our finding that the clinical progression of the disease and the associated symptoms paralleled changes in the CSF NMDAR antibody titer, we speculate that the lesions formed as a result of anti-NMDAR encephalitis.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article