Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis.
J Am Chem Soc
; 137(17): 5654-7, 2015 May 06.
Article
em En
| MEDLINE
| ID: mdl-25881929
ABSTRACT
The direct conversion of aliphatic carboxylic acids to the corresponding alkyl fluorides has been achieved via visible light-promoted photoredox catalysis. This operationally simple, redox-neutral fluorination method is amenable to a wide variety of carboxylic acids. Photon-induced oxidation of carboxylates leads to the formation of carboxyl radicals, which upon rapid CO2-extrusion and F(â¢) transfer from a fluorinating reagent yield the desired fluoroalkanes with high efficiency. Experimental evidence indicates that an oxidative quenching pathway is operable in this broadly applicable fluorination protocol.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Carboxílicos
/
Hidrocarbonetos Fluorados
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article