Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells.
Nucleic Acid Ther
; 25(3): 121-9, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25894614
ABSTRACT
Covalent binding of squalene to siRNA has already been shown to be an interesting way of delivering siRNA in vivo. Whether squalene derivatives could also be used to deliver siRNA in cells without covalent binding similar to usual transfection with cationic lipids is the question addressed in this article. Accordingly, we investigated the activity of two squalene derivatives bearing a quaternary ammonium head group and a guanidinium group, respectively. The second derivative displayed interesting properties for delivering siRNA into cells in vitro.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esqualeno
/
RNA Interferente Pequeno
/
Líquidos Iônicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article