Your browser doesn't support javascript.
loading
Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus.
Yano, Shuya; Miwa, Shinji; Kishimoto, Hiroyuki; Toneri, Makoto; Hiroshima, Yukihiko; Yamamoto, Mako; Bouvet, Michael; Urata, Yasuo; Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi; Hoffman, Robert M.
Afiliação
  • Yano S; AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA; Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  • Miwa S; AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
  • Kishimoto H; Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  • Toneri M; AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
  • Hiroshima Y; AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
  • Yamamoto M; AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
  • Bouvet M; Department of Surgery, University of California San Diego, San Diego, California, USA.
  • Urata Y; Oncolys BioPharm Inc., Tokyo, Japan.
  • Tazawa H; Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
  • Kagawa S; Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  • Fujiwara T; Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  • Hoffman RM; AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA. Electronic address: all@anticancer.com.
Mol Ther ; 23(7): 1182-1188, 2015 Jul.
Article em En | MEDLINE | ID: mdl-25896244
ABSTRACT
Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glioblastoma / Proteínas de Fluorescência Verde / Fluorescência / Recidiva Local de Neoplasia Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glioblastoma / Proteínas de Fluorescência Verde / Fluorescência / Recidiva Local de Neoplasia Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article