A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress.

Lee, Jong Woo; Park, Hee Sun; Park, Sin-Aye; Ryu, Seung-Hee; Meng, Wuyi; Jürgensmeier, Juliane M; Kurie, Jonathan M; Hong, Waun Ki; Boyer, Julie L; Herbst, Roy S; Koo, Ja Seok

Lee, Jong Woo; Park, Hee Sun; Park, Sin-Aye; Ryu, Seung-Hee; Meng, Wuyi; Jürgensmeier, Juliane M; Kurie, Jonathan M; Hong, Waun Ki; Boyer, Julie L; Herbst, Roy S; Koo, Ja Seok.

Afiliação

Lee JW; Section of Medical Oncology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale School of Medicine, Yale University, New Haven, CT 06520, United States of America.
Park HS; Section of Medical Oncology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale School of Medicine, Yale University, New Haven, CT 06520, United States of America.
Park SA; Section of Medical Oncology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale School of Medicine, Yale University, New Haven, CT 06520, United States of America.
Ryu SH; Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Meng W; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, United States of America.
Jürgensmeier JM; Section of Medical Oncology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale School of Medicine, Yale University, New Haven, CT 06520, United States of America.
Kurie JM; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America.
Hong WK; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America.
Boyer JL; Section of Medical Oncology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale School of Medicine, Yale University, New Haven, CT 06520, United States of America.
Herbst RS; Section of Medical Oncology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale School of Medicine, Yale University, New Haven, CT 06520, United States of America; Translational Research Program, Yale Comprehensive Cancer Center, New Haven, CT 06520, United States of America.
Koo JS; Section of Medical Oncology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale School of Medicine, Yale University, New Haven, CT 06520, United States of America; Translational Research Program, Yale Comprehensive Cancer Center, New Haven, CT 06520, United States of America.

PLoS One ; 10(4): e0122628, 2015.

Article em En | MEDLINE | ID: mdl-25897662

Assuntos

Anilidas/farmacologia; Antineoplásicos/farmacologia; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/antagonistas & inibidores; Organofosfatos/farmacologia; Fragmentos de Peptídeos/antagonistas & inibidores; Sialoglicoproteínas/antagonistas & inibidores; Adenocarcinoma/metabolismo; Adenocarcinoma/mortalidade; Adenocarcinoma/patologia; Adenocarcinoma de Pulmão; Anilidas/química; Antineoplásicos/química; Proteínas Reguladoras de Apoptose/metabolismo; Autofagia; Proteína 7 Relacionada à Autofagia; Proteína 11 Semelhante a Bcl-2; Pontos de Checagem do Ciclo Celular; Linhagem Celular Tumoral; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/química; Ensaios de Seleção de Medicamentos Antitumorais; Estresse do Retículo Endoplasmático; Humanos; Concentração Inibidora 50; Estimativa de Kaplan-Meier; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/mortalidade; Neoplasias Pulmonares/patologia; Proteínas de Membrana/metabolismo; Simulação de Acoplamento Molecular; Organofosfatos/química; Fragmentos de Peptídeos/química; Modelos de Riscos Proporcionais; Ligação Proteica; Proteínas Proto-Oncogênicas/metabolismo; Sialoglicoproteínas/química; Enzimas Ativadoras de Ubiquitina/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Organofosfatos / Sialoglicoproteínas / Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico / Anilidas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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