Storage of washed or irradiated red cells in AS-7 improves their in vitro characteristics.
Vox Sang
; 109(3): 203-13, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-25900147
ABSTRACT
BACKGROUND:
AS-7 is a new alkaline hypotonic red cell additive solution (AS) shown to improve red cell quality during storage compared with AS-1. We sought to compare red cells stored in AS-7 with those stored in SAGM using RCC that were either untreated, or washed or irradiated on day 14 of storage. STUDY DESIGN ANDMETHODS:
A pooled and split study design was used to produce seven identical RCC (four in SAGM and three in AS-7). At day 14 following donation, two RCC (one in SAGM and one in AS-7) were gamma irradiated and three RCC (two in SAGM and one in AS-7) were washed and resuspended in either SAGM or AS-7. RCC were sampled for analysis throughout storage and at end of shelf life day 28 for washed or irradiated and day 35 for untreated RCC.RESULTS:
For untreated, washed or irradiated RCC, those stored in AS-7 had lower haemolysis, red cell microvesicles and supernatant potassium content than RCC in SAGM. In addition, ATP levels and pH were better maintained in AS-7 RCC than in SAGM RCC.CONCLUSION:
These data suggest that the quality of these components may be improved by storage in AS-7 compared with SAGM.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preservação de Sangue
/
Eritrócitos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article