Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders.
Bioorg Med Chem Lett
; 25(10): 2247-50, 2015.
Article
em En
| MEDLINE
| ID: mdl-25900218
ABSTRACT
Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (-)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10mg/kg, p.o.), without impairing animals locomotor activity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Piridinas
/
Doenças do Sistema Nervoso Central
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article