Synthesis, DNA-binding properties, and antitumor activity of novel distamycin derivatives.
J Med Chem
; 32(4): 774-8, 1989 Apr.
Article
em En
| MEDLINE
| ID: mdl-2590277
ABSTRACT
A group of potential alkylating agents have been synthesized that are structurally related to the oligopeptide antiviral antibiotic distamycin. All derivatives form complexes with native calf-thymus DNA but compounds 2, 3, and 6 give rise to covalent adducts. Cytostatic activity against both human and murine tumor cell lines in vitro is displayed by the new compounds. Compounds 3 and 4 are active on melphalan-resistant L1210 leukemia in mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
DNA
/
Distamicinas
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article