Scutellarin attenuates endothelium-dependent aasodilation impairment induced by hypoxia reoxygenation, through regulating the PKG signaling pathway in rat coronary artery.

Chen, Ya-Juan; Wang, Lei; Zhou, Guang-Yu; Yu, Xian-Lun; Zhang, Yong-Hui; Hu, Na; Li, Qing-Qing; Chen, Chen; Qing, Chen; Liu, Ying-Ting; Yang, Wei-Min

Chen, Ya-Juan; Wang, Lei; Zhou, Guang-Yu; Yu, Xian-Lun; Zhang, Yong-Hui; Hu, Na; Li, Qing-Qing; Chen, Chen; Qing, Chen; Liu, Ying-Ting; Yang, Wei-Min.

Afiliação

Chen YJ; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Wang L; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Zhou GY; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Yu XL; Zhaotong Institute of Tianma, Zhaotong 657000, China.
Zhang YH; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Hu N; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Li QQ; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Chen C; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Qing C; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Liu YT; Department of Periodontology and Implant Dentistry, The First People's Hospital of Yun-Nan Province, Kunhua Hospital Affiliated to Kunming University of Science and Technology, Kunming 650032, China. Electronic address: liuyingting999@163.com.
Yang WM; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China. Electronic address: ywmbessie@yeah.net.

Chin J Nat Med ; 13(4): 264-73, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25908623

Assuntos

Apigenina/farmacologia; Hipóxia Celular; Vasos Coronários/efeitos dos fármacos; Glucuronatos/farmacologia; Traumatismo por Reperfusão/fisiopatologia; Vasodilatação/efeitos dos fármacos; Animais; Moléculas de Adesão Celular/efeitos dos fármacos; GMP Cíclico/análogos & derivados; GMP Cíclico/metabolismo; GMP Cíclico/farmacologia; Proteínas Quinases Dependentes de GMP Cíclico; Proteínas dos Microfilamentos/efeitos dos fármacos; NG-Nitroarginina Metil Éster/metabolismo; NG-Nitroarginina Metil Éster/farmacologia; Fosfoproteínas/efeitos dos fármacos; Ratos; Ratos Sprague-Dawley; Traumatismo por Reperfusão/complicações; Transdução de Sinais/efeitos dos fármacos; Tionucleotídeos/metabolismo; Tionucleotídeos/farmacologia; Vasodilatação/fisiologia

Palavras-chave

Coronary artery; Endothelium-dependent vasodilation; Hypoxia reoxygenation; Rat; Scutellarin; cGMP-dependent protein kinase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasodilatação / Traumatismo por Reperfusão / Hipóxia Celular / Vasos Coronários / Apigenina / Glucuronatos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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