Fine-tuning of T-cell development by the CD3Î³ di-leucine-based TCR-sorting motif.

Lauritsen, Jens Peter H; Boding, Lasse; Buus, Terkild B; Kongsbak, Martin; Levring, Trine B; Rode, Anna K O; Bonefeld, Charlotte Menné; Geisler, Carsten

Lauritsen, Jens Peter H; Boding, Lasse; Buus, Terkild B; Kongsbak, Martin; Levring, Trine B; Rode, Anna K O; Bonefeld, Charlotte Menné; Geisler, Carsten.

Afiliação

Lauritsen JP; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Boding L; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Buus TB; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Kongsbak M; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Levring TB; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Rode AK; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Bonefeld CM; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Geisler C; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark cge@sund.ku.dk.

Int Immunol ; 27(8): 393-404, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25920998

Assuntos

Alanina/metabolismo; Complexo CD3/genética; Leucina/metabolismo; Timócitos/imunologia; Alanina/imunologia; Motivos de Aminoácidos; Substituição de Aminoácidos; Animais; Apoptose; Complexo CD3/imunologia; Linfócitos T CD4-Positivos/citologia; Linfócitos T CD4-Positivos/imunologia; Antígenos CD8/genética; Antígenos CD8/imunologia; Linfócitos T CD8-Positivos/citologia; Linfócitos T CD8-Positivos/imunologia; Diferenciação Celular; Proliferação de Células; Células Clonais; Regulação da Expressão Gênica; Imunofenotipagem; Leucina/imunologia; Camundongos; Camundongos Transgênicos; Dados de Sequência Molecular; Proteínas Proto-Oncogênicas c-bcl-2/genética; Proteínas Proto-Oncogênicas c-bcl-2/imunologia; Transdução de Sinais; Timócitos/citologia

Palavras-chave

T-cell receptor; development; down-regulation; thymocyte

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexo CD3 / Alanina / Timócitos / Leucina Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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