Development of stapled helical peptides to perturb the Cdt1-Mcm6 interaction.
J Pept Sci
; 21(7): 593-8, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25921752
ABSTRACT
Six all-hydrocarbon-stapled Cdt1 MBD-derived peptides have been designed and synthesized to perturb the Cdt1-Mcm6 interaction, which is involved in DNA replication. Inconsistency between the helicity of the obtained peptidomimetics and their binding affinity has been observed. The helicity of 13-amino acid stapled peptides increased, while their binding to Mcm6 was decreased. On the other hand, the 30-amino acid stapled peptides exhibited decreased helicity but increased binding affinity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Proteínas de Ciclo Celular
/
Peptidomiméticos
/
Componente 6 do Complexo de Manutenção de Minicromossomo
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article