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Enantioselective N-heterocyclic carbene-catalyzed synthesis of trifluoromethyldihydropyridinones.
Wang, Dong-Ling; Liang, Zhi-Qin; Chen, Kun-Quan; Sun, De-Qun; Ye, Song.
Afiliação
  • Wang DL; †Marine College, Shandong University at Weihai, 180 Wenhua West Road, Weihai 264209, China.
  • Liang ZQ; ‡Beijing National Laboratory for Molecular Science, Key Laboratory of Molecular Recognition and Functional, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
  • Chen KQ; ‡Beijing National Laboratory for Molecular Science, Key Laboratory of Molecular Recognition and Functional, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
  • Sun DQ; †Marine College, Shandong University at Weihai, 180 Wenhua West Road, Weihai 264209, China.
  • Ye S; ‡Beijing National Laboratory for Molecular Science, Key Laboratory of Molecular Recognition and Functional, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
J Org Chem ; 80(11): 5900-5, 2015 Jun 05.
Article em En | MEDLINE | ID: mdl-25933360
ABSTRACT
The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of α-chloroaldehydes and trifluoromethyl N-Boc azadienes was developed, giving the corresponding 3,4-disubstituted-6-trifluoromethyldihydropyridin-2(1H)-ones in good yields with exclusive cis-selectivities and excellent enantioselectivities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article