Drosophila melanogaster Hedgehog cooperates with Frazzled to guide axons through a non-canonical signalling pathway.
Mech Dev
; 137: 11-22, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25936631
ABSTRACT
We report that the morphogen Hedgehog (Hh) is an axonal chemoattractant in the midline of Drosophila melanogaster embryos. Hh is present in the ventral nerve cord during axonal guidance and overexpression of hh in the midline causes ectopic midline crossing of FasII-positive axonal tracts. In addition, we show that Hh influences axonal guidance via a non-canonical signalling pathway dependent on Ptc. Our results reveal that the Hh pathway cooperates with the Netrin/Frazzled pathway to guide axons through the midline in invertebrates.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Transdução de Sinais
/
Receptores de Superfície Celular
/
Proteínas de Drosophila
/
Drosophila melanogaster
/
Ouriços
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article