An astrocyte-dependent mechanism for neuronal rhythmogenesis.
Nat Neurosci
; 18(6): 844-54, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25938883
ABSTRACT
Communication between neurons rests on their capacity to change their firing pattern to encode different messages. For several vital functions, such as respiration and mastication, neurons need to generate a rhythmic firing pattern. Here we show in the rat trigeminal sensori-motor circuit for mastication that this ability depends on regulation of the extracellular Ca(2+) concentration ([Ca(2+)]e) by astrocytes. In this circuit, astrocytes respond to sensory stimuli that induce neuronal rhythmic activity, and their blockade with a Ca(2+) chelator prevents neurons from generating a rhythmic bursting pattern. This ability is restored by adding S100ß, an astrocytic Ca(2+)-binding protein, to the extracellular space, while application of an anti-S100ß antibody prevents generation of rhythmic activity. These results indicate that astrocytes regulate a fundamental neuronal property the capacity to change firing pattern. These findings may have broad implications for many other neural networks whose functions depend on the generation of rhythmic activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Periodicidade
/
Astrócitos
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article