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CD 30-positive transformed follicular lymphoma: two case reports and literature review.
Montes-Moreno, Santiago; Climent, Fina; González de Villambrosía, Sonia; González Barca, Eva M; Batlle, Ana; Insunza, Andrés; Pané-Foix, María; Colorado, Mercedes; Martin-Sánchez, Guillermo; Espiga, Carlos Richard; Conde, Eulogio; Piris, Miguel A.
Afiliação
  • Montes-Moreno S; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
  • Climent F; Pathology and Hematology Departments, ICO, Hospital Universitari de Bellvitge, Barcelona, Spain.
  • González de Villambrosía S; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
  • González Barca EM; Pathology and Hematology Departments, ICO, Hospital Universitari de Bellvitge, Barcelona, Spain.
  • Batlle A; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
  • Insunza A; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
  • Pané-Foix M; Pathology and Hematology Departments, ICO, Hospital Universitari de Bellvitge, Barcelona, Spain.
  • Colorado M; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
  • Martin-Sánchez G; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
  • Espiga CR; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
  • Conde E; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
  • Piris MA; Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
Histopathology ; 67(6): 918-22, 2015 Dec.
Article em En | MEDLINE | ID: mdl-25953530
ABSTRACT

AIMS:

Here we report two cases of follicular lymphoma that transformed to CD30 positive diffuse large B cell lymphoma and review the literature on this topic.

RESULTS:

The first case represents an example of early transformation of conventional low-grade follicular lymphoma to CD30-positive large B cell lymphoma. Immunoglobulin (Ig)H and cytogenetic identity was demonstrated between both components. High-dose and auto-stem cell transplant (SCT) was applied and complete response was achieved. The second case represents an example of d'emblee transformation of intrafollicular neoplasia to CD30-positive large B cell lymphoma. Immunoglobulin K deleting element (IgKde) and cytogenetic identity between both phases was demonstrated. The patient was in partial response after four cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP).

CONCLUSIONS:

CD30 expression was found to be associated in these cases to the transformation event and could be considered a therapeutic target to add to conventional immunochemotherapeutic regimens, even in combination with auto-SCT. We suggest looking for CD30 expression in transformed follicular lymphoma cases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / Linfoma Folicular / Linfoma Difuso de Grandes Células B / Antígeno Ki-1 Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / Linfoma Folicular / Linfoma Difuso de Grandes Células B / Antígeno Ki-1 Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article