A NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus.
EMBO J
; 34(13): 1786-800, 2015 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-25953831
ABSTRACT
Coupling cell cycle with nutrient availability is a crucial process for all living cells. But how bacteria control cell division according to metabolic supplies remains poorly understood. Here, we describe a molecular mechanism that coordinates central metabolism with cell division in the α-proteobacterium Caulobacter crescentus. This mechanism involves the NAD-dependent glutamate dehydrogenase GdhZ and the oxidoreductase-like KidO. While enzymatically active GdhZ directly interferes with FtsZ polymerization by stimulating its GTPase activity, KidO bound to NADH destabilizes lateral interactions between FtsZ protofilaments. Both GdhZ and KidO share the same regulatory network to concomitantly stimulate the rapid disassembly of the Z-ring, necessary for the subsequent release of progeny cells. Thus, this mechanism illustrates how proteins initially dedicated to metabolism coordinate cell cycle progression with nutrient availability.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Divisão Celular
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Caulobacter crescentus
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Glutamato Desidrogenase
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article