Retinal nerve fiber layer structure abnormalities in patients with Neuro-Behcet's disease.
Graefes Arch Clin Exp Ophthalmol
; 253(7): 1181-5, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25957000
ABSTRACT
PURPOSE:
Our aim was the evaluation of retinal nerve fiber layer (RNFL) and central macular thickness (CMT) in patients with Neuro-Behcet's disease (NBD) and to compare the results with healthy control subjects.METHODS:
We recruited 50 eyes of 25 patients with NBD and 42 eyes of 21 age-matched healthy control subjects. Patients and control subjects underwent a thorough ophthalmic examination, including retinal nerve fiber layer and macular thickness measurements by optical coherence tomography.RESULTS:
No significant difference was found between groups for age, sex, intra-ocular pressure and central corneal thickness measurements. The average RNFL in patients with NBD was significantly lower than that of healthy controls (86.92 ± 18.36 µm vs. 99.74 ± 8.73 µm; p = 0.00). There was significant thinning of the RNFL in three of four quadrants of the peripapillary area, superior (107.22 ± 30.91 µm vs. 125.57 ± 20.97 µm; p = 0.00), inferior (110.36 ± 25.57 µm vs. 132.19 ± 12.71 µm; p = 0.00) and nasal (68.84 ± 18.47 µm vs. 74.98 ± 11.42 µm; p = 0.05), in patients with NBD. Average CMT was significantly lower in NBD patients than in control subjects (244.06 ± 26.25 µm vs. 261.69 ± 25.71 µm; p = 0.00).CONCLUSIONS:
There are significant differences in average RNFL and CMT between the two groups. RNFL and CMT thicknesses are reduced in patients with NBD compared with the healthy controls.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Ganglionares da Retina
/
Encefalopatias
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Doenças do Nervo Óptico
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Síndrome de Behçet
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Fibras Nervosas
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article