Halogenative difluorohomologation of ketones.
J Org Chem
; 80(11): 5870-6, 2015 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-25965426
ABSTRACT
A method for the difluorohomologation of ketones accompanied by halogenation of a C-H bond is described. The reaction involves silylation, difluorocarbene addition using Me3SiCF2Br activated by a bromide ion, and halogenation of intermediate cyclopropanes with N-bromo- or N-iodosuccinimide. The whole process is performed without isolation of intermediates. The resulting α,α-difluoro-ß-halo-substituted ketones can be readily converted into fluorine containing pyrazole derivatives and oxetanes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Éteres Cíclicos
/
Hidrocarbonetos Fluorados
/
Cetonas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article