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Widespread seasonal gene expression reveals annual differences in human immunity and physiology.
Dopico, Xaquin Castro; Evangelou, Marina; Ferreira, Ricardo C; Guo, Hui; Pekalski, Marcin L; Smyth, Deborah J; Cooper, Nicholas; Burren, Oliver S; Fulford, Anthony J; Hennig, Branwen J; Prentice, Andrew M; Ziegler, Anette-G; Bonifacio, Ezio; Wallace, Chris; Todd, John A.
Afiliação
  • Dopico XC; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Evangelou M; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Ferreira RC; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Guo H; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Pekalski ML; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Smyth DJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Cooper N; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Burren OS; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Fulford AJ; MRC International Nutrition Group at MRC Unit The Gambia &London School of Hygiene &Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
  • Hennig BJ; MRC International Nutrition Group at MRC Unit The Gambia &London School of Hygiene &Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
  • Prentice AM; MRC International Nutrition Group at MRC Unit The Gambia &London School of Hygiene &Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
  • Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstaedter Landstr. 1, D 85764 Neuherberg, Germany.
  • Bonifacio E; CRTD-DFG Research Center for Regenerative Therapies Dresden, Paul Langerhans Institute Dresden, Medical Faculty, Technische Universität Dresden, Fetscherstrasse, 01307 Dresden, Germany.
  • Wallace C; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  • Todd JA; MRC Biostatistics Unit, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK.
Nat Commun ; 6: 7000, 2015 May 12.
Article em En | MEDLINE | ID: mdl-25965853
Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estações do Ano / Regulação da Expressão Gênica / Genes MHC da Classe II / Fatores de Transcrição ARNTL Limite: Adolescent / Adult / Aged / Child / Child, preschool / Humans / Infant / Middle aged / Newborn País/Região como assunto: Africa / Europa / Oceania Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estações do Ano / Regulação da Expressão Gênica / Genes MHC da Classe II / Fatores de Transcrição ARNTL Limite: Adolescent / Adult / Aged / Child / Child, preschool / Humans / Infant / Middle aged / Newborn País/Região como assunto: Africa / Europa / Oceania Idioma: En Ano de publicação: 2015 Tipo de documento: Article