Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding.
MAbs
; 7(4): 743-51, 2015.
Article
em En
| MEDLINE
| ID: mdl-25970007
Palavras-chave
ADCC; ADCC, antibody-dependent cell-mediated cytotoxicity; ADCP, antibody-dependent cell-mediated phagocytosis; AUC, area under the curve; CL, clearance rate; CD89; CDC, complement dependent cytotoxicity; Cmax, maximum serum concentration; DSC, differential scanning calorimetry; E:T ratio, effector to target ratio; FCM, flow cytometry; FcRn, neonatal Fc receptor; FcαRI; FcγR, Fc gamma receptor; HER2, human epithelial receptor two; IgA; IgA, immunoglobulin A; IgG, immunoglobulin G; LDH, lactate dehydrogenase; MΦ, macrophage; NK, natural killer; PBMC, peripheral blood mononuclear cell; PK, pharmacokinetics; PMN, polymorphonuclear; SPR, surface plasmon resonance; TAA, tumor associated antigens; T½, half-life; Vss, central compartment volume of distribution; macrophage; monoclonal antibody; neutrophil; tandem; trastuzumab
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Imunoglobulina G
/
Receptores Fc
/
Antígenos CD
/
Leucócitos
/
Citotoxicidade Celular Dependente de Anticorpos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article