Synthesis, antimycobacterial evaluation and pharmacophore modeling of analogues of the natural product formononetin.

Mutai, Peggoty; Pavadai, Elumalai; Wiid, Ian; Ngwane, Andile; Baker, Bienyameen; Chibale, Kelly

Mutai, Peggoty; Pavadai, Elumalai; Wiid, Ian; Ngwane, Andile; Baker, Bienyameen; Chibale, Kelly.

Afiliação

Mutai P; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Pavadai E; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Wiid I; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa.
Ngwane A; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa.
Baker B; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa.
Chibale K; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; South African Medical Research Council, Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape To

Bioorg Med Chem Lett ; 25(12): 2510-3, 2015 Jun 15.

Article em En | MEDLINE | ID: mdl-25977095

Assuntos

Antituberculosos/síntese química; Produtos Biológicos/síntese química; Isoflavonas/química; Isoflavonas/síntese química; Antituberculosos/química; Antituberculosos/farmacologia; Produtos Biológicos/química; Produtos Biológicos/farmacologia; Desenho de Fármacos; Isoflavonas/farmacologia; Testes de Sensibilidade Microbiana; Mycobacterium tuberculosis/efeitos dos fármacos; Relação Estrutura-Atividade

Palavras-chave

Activity; Antimycobacterial; Formononetin; Pharmacophore; Structure

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Isoflavonas / Antituberculosos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google