Mechanical stretch enhances the expression and activity of osteopontin and MMP-2 via the Akt1/AP-1 pathways in VSMC.

Seo, Kyo Won; Lee, Seung Jin; Ye, Byeong Hyeok; Kim, Young Whan; Bae, Sun Sik; Kim, Chi Dae

Seo, Kyo Won; Lee, Seung Jin; Ye, Byeong Hyeok; Kim, Young Whan; Bae, Sun Sik; Kim, Chi Dae.

Afiliação

Seo KW; Department of Pharmacology, School of Medicine, and Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of Korea.
Lee SJ; Department of Pharmacology, School of Medicine, and Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of Korea.
Ye BH; Department of Pharmacology, School of Medicine, and Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of Korea.
Kim YW; Department of Pharmacology, School of Medicine, and Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of Korea.
Bae SS; Department of Pharmacology, School of Medicine, and Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of Korea.
Kim CD; Department of Pharmacology, School of Medicine, and Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of Korea. Electronic address: chidkim@pusan.ac.kr.

J Mol Cell Cardiol ; 85: 13-24, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25986148

Assuntos

Hipertensão/metabolismo; Metaloproteinase 2 da Matriz/metabolismo; Miócitos de Músculo Liso/fisiologia; Osteopontina/sangue; Animais; Sítios de Ligação; Fenômenos Biomecânicos; Células Cultivadas; Sequência Consenso; Receptores de Hialuronatos/metabolismo; Hipertensão/patologia; Masculino; Mecanotransdução Celular; Camundongos Endogâmicos C57BL; Músculo Liso Vascular/patologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos Endogâmicos SHR; Ratos Endogâmicos WKY; Transdução de Sinais; Fator de Transcrição AP-1/metabolismo; Remodelação Vascular

Palavras-chave

Hypertension; MMP; Mechanical stretch; OPN; VSMC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metaloproteinase 2 da Matriz / Miócitos de Músculo Liso / Osteopontina / Hipertensão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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