Diabetes mellitus and the risk of bladder cancer: an Italian casecontrol study.
Br J Cancer
; 113(1): 127-30, 2015 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-25996204
ABSTRACT
BACKGROUND:
Diabetes mellitus has been associated with an increased risk of bladder cancer, although the evidence is still open to discussion.METHODS:
We examined this association using data from a multicentre Italian casecontrol study, conducted between 2003 and 2014 on 690 bladder cancer cases and 665 frequency-matched hospital controls. Odds ratios (ORs) for diabetes were estimated by unconditional multiple logistic regression models, after allowance for major known risk factors for bladder cancer.RESULTS:
One hundred and twelve (16.2%) cases and 57 (8.6%) controls reported a diagnosis of diabetes mellitus, corresponding to a multivariate OR of 2.09 (95% confidence interval (CI) 1.463.01). Bladder cancer risk increased with duration of diabetes (OR 1.92 for 1 <5 years, 1.63 for 5 <10 years, 2.39 for 10 <15 years, and 2.58 for ≥15 years). The increased risk of bladder cancer was consistent in strata of age and education, whereas it was somewhat lower (although not significantly) in women (OR 1.18), in never (OR 1.31) and current (OR 1.42) smokers, and in subjects with a body mass index <25 kg m(-2) (OR 1.48).CONCLUSION:
The present study provides further support of a role of diabetes in bladder cancer aetiology, although some residual confounding by tobacco, body mass index, or other unmeasured covariates may partly explain the association observed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
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Carcinoma de Células de Transição
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Complicações do Diabetes
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
/
Aged80
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Humans
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article