Association of TNFSF15 polymorphisms in Korean children with Crohn's disease.
Pediatr Int
; 57(6): 1149-53, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-25998826
ABSTRACT
BACKGROUND:
Genome-wide association studies have identified tumor necrosis factor superfamily member 15 (TNFSF15) as a Crohn's disease (CD)-related gene. The aim of this study was to evaluate the association between five TNFSF15 polymorphisms and CD in Korean children and analyze their genotypes in relation to phenotype.METHODS:
Five single-nucleotide polymorphisms of TNFSF15 (rs3810936, rs6478108, rs6478109, rs7848647, rs7865494) were genotyped in 108 CD patients and in 599 healthy controls. Risk allele, genotype, and haplotype were analyzed in CD patients and controls, and genotype-phenotype relationships were studied.RESULTS:
There were significant associations of rs3810936, rs6478108, rs6478109, rs7848647 with CD in Korean pediatric patients (P = 6.5×10(-8), P = 1.3×10(-8), P = 3.7×10(-8), P = 2.9×10(-8), respectively). The adjusted OR (aOR) for the homozygous risk allele genotype was significantly higher than that for the homozygous genotype for the opposite allele rs3810936, aOR, 5.36 (95%CI 2.61-10.98, P = 4.6×10(-6)); rs6478108, aOR, 6.62 (95%CI 3.03-14.46, P = 2.2×10(-6)); rs6478109, aOR, 6.24 (95%CI 2.85-13.66, P = 4.6×10(-6)); rs7848647, aOR, 6.32 (95%CI 2.89-13.81, P = 3.8×10(-6)). The risk allele of rs3810936 was associated with later symptom onset, later diagnosis, and the presence of perianal lesion (P = 0.013, P = 0.016 and P = 0.029).CONCLUSION:
There was a significant association of TNFSF15 with pediatric CD in Korean patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
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Colite Ulcerativa
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Doença de Crohn
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Membro 15 da Superfamília de Ligantes de Fatores de Necrose Tumoral
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Estudo de Associação Genômica Ampla
Tipo de estudo:
Incidence_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article