Inhibitory activities of biflavonoids against amyloid-ß peptide 42 cytotoxicity in PC-12 cells.
Bioorg Med Chem Lett
; 25(14): 2831-3, 2015 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-26004578
ABSTRACT
A major hallmark of Alzheimer's disease is the cerebral accumulation and resulting cytotoxicity of amyloid-ß peptides, particularly Aß42. In this study, we used an MTT assay to investigate the inhibitory activity of biflavonoids 1-22 against Aß42 cytotoxicity in PC-12 cell cultures. Cytoprotective effects were observed for the following amentoflavone type biflavonoids podocarpusflavone B 8, isoginkgetin 10, sciadopitysin 13, and kayaflavone 15. These biflavonoids exhibited strong activity in tested compounds, with EC50 values of 5.18, 10.77, 9.84, and 5.29 µM, respectively. Cell viability tests of PC-12 cells revealed that biflavonoids 13 and 15 had stronger inhibitory activities than apigenin 23 and (-)-epigallocatechin gallate 24.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Sobrevivência Celular
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Peptídeos beta-Amiloides
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Substâncias Protetoras
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Biflavonoides
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article