Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.

Cho, Jong Hyun; Coats, Steven J; Schinazi, Raymond F

Cho, Jong Hyun; Coats, Steven J; Schinazi, Raymond F.

Afiliação

Cho JH; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Atlanta, GA 30322, USA.
Coats SJ; RFS Pharma, 1860 Montreal Road Tucker, GA 30084, USA.
Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Atlanta, GA 30322, USA.

Tetrahedron Lett ; 56(23): 3587-3590, 2015 Jun 03.

Article em En | MEDLINE | ID: mdl-26028788

ABSTRACT

ABSTRACT

New carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases were synthesized and evaluated as potential anti-HIV and anti-HCV agents. Among the synthesized carbocyclic nucleoside analogs, the pyrazole amide 15f exhibited modest selective anti-HIV-1 activity (EC50 = 24 µM).

Palavras-chave

antiviral; carbocyclic ribonucleoside; five-membered nucleobases

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article