Phospholipase A2 receptor positive membranous nephropathy long after living donor kidney transplantation between identical twins.
Nephrology (Carlton)
; 20 Suppl 2: 101-4, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26031599
ABSTRACT
Although membranous nephropathy (MN) is a commonly observed cause of post-transplant glomerulonephritis, distinguishing de novo from recurrent MN in kidney allograft is often difficult. Phospholipase A2 receptor (PLA2R) staining is useful for diagnosing recurrent MN in allografts similarly to idiopathic MN in native kidney. No specific treatment strategy has been established for MN, especially when accompanied with HCV infection in kidney transplant recipients. This report describes a 66-year-old man who was diagnosed as having PLA2R positive membranous nephropathy accompanied with already-known IgA nephropathy and HCV infection 26 years after kidney transplantation conducted between identical twins. PLA2R was detected along capillary loops, implying that this patient is affected by the same pathogenic mechanism as idiopathic MN, not secondary MN associated with other disorders such as HCV infection. The patient successfully achieved clinical remission after steroid therapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glomerulonefrite Membranosa
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Transplante de Rim
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Doadores Vivos
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Doenças em Gêmeos
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Receptores da Fosfolipase A2
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Rim
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Falência Renal Crônica
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
Limite:
Adult
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Aged
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article