Tobramycin Variants with Enhanced Ribosome-Targeting Activity.

Fosso, Marina Y; Zhu, Hongkun; Green, Keith D; Garneau-Tsodikova, Sylvie; Fredrick, Kurt

Fosso, Marina Y; Zhu, Hongkun; Green, Keith D; Garneau-Tsodikova, Sylvie; Fredrick, Kurt.

Afiliação

Fosso MY; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone, Lexington, KY 40536-0596 (USA).
Zhu H; Department of Microbiology, Center for RNA Biology, Ohio State University, 484 W. 12th Avenue, Columbus, OH 43210-1292 (USA).
Green KD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone, Lexington, KY 40536-0596 (USA).
Garneau-Tsodikova S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone, Lexington, KY 40536-0596 (USA). sylviegtsodikova@uky.edu.
Fredrick K; Department of Microbiology, Center for RNA Biology, Ohio State University, 484 W. 12th Avenue, Columbus, OH 43210-1292 (USA). fredrick.5@osu.edu.

Chembiochem ; 16(11): 1565-70, 2015 Jul 27.

Article em En | MEDLINE | ID: mdl-26033429

Assuntos

Antibacterianos/química; Antibacterianos/farmacologia; Ribossomos/efeitos dos fármacos; Tobramicina/química; Tobramicina/farmacologia; Antibacterianos/metabolismo; Escherichia coli/citologia; Escherichia coli/efeitos dos fármacos; Escherichia coli/enzimologia; Tobramicina/metabolismo

Palavras-chave

aminoglycoside; antibacterial agents; bacterial resistance; drug-modifying enzymes; translocation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribossomos / Tobramicina / Antibacterianos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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